Hey Paulie,
Welcome to the forum! I took the following from Kyle's wonderful "Encyclopedia of Joe Bonamassa Guitar Help" Thread. Maybe this will shed some light . . .
I'm a mainly a strat player, so I have no advice for you in that department. Otherwise, hang tight, you've come to the right place. I'm sure someone here can help you out!
Congratulations on playing again!
In relation to set up of his Les Paul:
I use 11-52 Dean Markely strings. I use high action.. Its important on a Les Paul that the truss rod is adjusted properly.. A poorly adjusted truss will make play horribly out of tune and intonation. Proper nut adjustment will also be a factor. Dave uses Nut Sauce on the gibsons and frankly makes them sound so intune. Light years ahead of what I could ever do. The big frets are a help and use them to your advantage. Also wrap the strings around the bridge then go over the saddles.(Jimmy Page, Billy Gibbons style) It helps make the heavy strings feel lighter.. Most people who play my guitars think they are 10's. Good Luck and Happy holidays.. ??Oh Oh I forgot.. set up your guitar without the amp.. Make it sound good acoustically then plug it in.. thats what I have learned is a good sounding electric guitar will sound good and warm without a amp..
"There is nothing to it. You only have to hit the right notes at the right time and the instrument plays itself."---Johann Sebastian Bach