WE are really in the golden age of guitars & custom amps right now I do believe. Bunch of great builders in USA that have waiting lists; and are up there in price. These guys build it all from scratch, even their own pups. Top builders strats & teles start 1800-2000 and up. Gibson clones more like 3-4. I don't think I would ever buy new a stock gibson or fender again.
I had a local builder here in Alaska (thinking regional) build me a tele and it's ok, way better than any stk or fender custom shop amer tele but in retrospect I would have went to a more nationally known builder. There's a half dozen builders out there across this country that are heads above everyone else, no joke. You will wait 8 months after throwing down gran deposit. The top builders have an edge on the rest, choosing wood, building necks, just balancing the whole deal together. The guitars they built 5 years back, that sold for 1000, have tripled in price. They only make so many, change models, hold their resale value; won't see these on craigs list. When you do see them on various emporiums, they go like right now.
My take on all the local builders who don't have long wait times is that they build good guitars and all, but the top builders do it better, more consistently, they got something extra figured out. All the local guys will have you play their favorite homemade guitar, then try to buy it off them. Even try to get a guarantee your guitar will be as good as their best build. Then, they will fess up that once in a while one of their builds is heads above the rest and they really don't know why. With the top builders, most of the buyers seem convinced or brainwashed they will never need another guitar.
Here's another take, many of the bigger pickup builders claim all in shop but actually you find out coming from overseas. You have to get to the small time guys, kiss their butts for their numbered, signed. dated handwounds; and you'll be amazed how much better they are. Remember QUANTITY does not make QUALITY.