-Agree with AD3, anymore I just use a tube screamer into a broken up amp for my desired tone, and another dirt pedal to boost it for leads. So having a reverb and delay before amp sounds just fine and I don't feel as if I'm having to compromise either.
-Like Devan I didn't care for the mess of additional cables, even though I tethered all my cables together like a snake with the ends exposed and labeled the ends, its less muss and fuss.
You'll find you can get a smoother tone from your reverb in the loop. It blends well with the tone on the front of the amp. I personally keep the reverb and delay volumes a bit lower with a longer decay. By doing so, they work well out front for me. I don't get that sudden hit of reverb after a dry tone like you do sometimes if the effect volume is higher.
I used to be a staunch effects loop user and advocator but not anymore. I'm happy with everything out front. They didn't have effects loops back in the day and things sounded pretty good. But if your amp has one, try it out and see what works I guess. I think the more you mess around with gear, the better your ear develops at picking up on different nuances etc... Never a bad idea to tweak things.