scale lengths, fretboard radii, body shape, neck shape, all will affect the touch. Different tones, different woods, all will affect the playability of an instrument. I go through phases where i favor one vs the other (LP vs Strat) that is, and based on the gig, as I play as a sideman, I have to taylor the tone to the music, from country to rock. I discovered solo JB when he was Budda/Marshall/Strat/bunch of pedals, and just making the transition to LP's. His live videos from that era have a fire and a sense of urgency that cannot be matched. Age, experience, all kinds of things influencing the playing/tone/approach, that is just tough to keep going without getting bored or repeating yourself. I mean Clapton went from Tele->Gibsons->Strats and his tone has changed drastically through the decades. I guess it is that whole thing about growing as an artist. I think JB's tone nowadays, to my ears, much like his technique, is more refined, less flash, better note choices. He is also playing with keyboards live, so no longer a trio. Really there seems to be a night and day difference between approaches from 2004 to 2012. I think there is something for everyone.
P.S. I even noticed that his stage presence and how he approaches the mic has changed. he used to be, in my opinion, very much influenced by BB King as a showman, up until the mid 2000's and nowadays I think he has found his own thing.
Amp: Firebird Musical Amplifiers
Guitars:62 LP SG , 02 FB VII, JB FB I, 76 Electra Omega, 64 Firebird V, 73 LPC, 61 Custom Tele, 59 and 60 Melody Maker
Effects: Mythos Chupacabra, Strymon Deco/Flint